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Pharma Is Hollywood, Roughly
How two industries with nothing in common converged on the same business model
May 11
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Alex Kesin
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They Put a TB Vaccine Where?!
BCG, bladder cancer, and drug repurposing from the weirdest of places
Mar 26
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Alex Kesin
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Anti-Amyloids and Antichrist
Some thoughts on Peter Thiel's view of the beta-amyloid hypothesis as a lens for understanding the messy, slow cost of figuring out how to make drugs…
Feb 2
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Alex Kesin
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Episode #1: Amylin Pharmaceuticals
Amylin pioneered the incretin class & staked their future on obesity 20+ yrs ago, yet sold for only $7B in 2012 - a pittance for the foundation of what…
Published on Approved
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Jan 30
1:46:27
A Better Proxy Than the Rat and Dog
How Axiom Bio is trying to fix drug safety testing.
Jan 8
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Alex Kesin
32
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Would Walter White Still Cook Meth in 2025?
Or: How Modern Oncology and Employer Insurance Would Have Ruined the Entire Premise
Dec 1, 2025
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Alex Kesin
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The three-thousand-year journey of colchicine
For centuries it was a poison. Then colchicine rewrote treatment for gout, heart disease, and later, the debate over drug exclusivity.
Published on The Works in Progress Newsletter
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Nov 20, 2025
Fun with FGF21
...Did everyone just panic-buy an FGF21?
Oct 14, 2025
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Alex Kesin's Pharmacopoeia
Ruminations about biotech and drug development - one overly earnest blog post at a time.
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Astral Codex Ten
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Clinical Significance
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Alex Kesin's Pharmacopoeia
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